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KMID : 1144720220260040200
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Investigative Magnetic Resonance Imaging
2022 Volume.26 No. 4 p.200 ~ p.207
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Diffusion MRI With High to Ultrahigh b-Values: How It Will Benefit the Discovery of Brain Microstructure and Pathological Changes
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Wongkornchaovalit Paween
Feng Min
He Hongjian
Zhong Jianhui
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Abstract
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Diffusion MRI (dMRI) has been widely utilized to probe the random motion of water molecules in tissues. In a dMRI acquisition protocol, diffusion weighting or b-value is one of the most important parameters to consider. In recent years, high and ultrahigh b-values have become popular partly due to advances in hardware. In this mini-review, we will discuss impacts of high/ultrahigh b-values in three different areas: brain microstructure, tractography, and clinical applications. We will emphasize advantages of high b-value in probing diffusion within highly restricted regions or fine structures with enhanced diffusion contrast. A short summary is included at the end of each section to illustrate both advantages and disadvantages of using a high/ultrahigh b-value for each purpose.
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KEYWORD
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Diffusion MRI, High b-value, Ultrahigh b-value, Brain microstructure, Diffusion tractography
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